英文名稱 | Triptolide (PG490) |
---|---|
中文名稱 | 雷公藤甲素 |
CAS號 | 38748-32-2 |
分子式 | C20H24O6 |
分子量 | 360.40 |
外觀 | white solid powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Triptolide (PG490) |
---|---|
中文名稱 | 雷公藤甲素 |
CAS號 | 38748-32-2 |
分子式 | C20H24O6 |
分子量 | 360.40 |
外觀 | white solid powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.