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重組人白介素 17A(rHuIL-17A)

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Recombinant Human Interleukin 17A (rHulL-l7A)

產(chǎn)品編號(hào):CLRP1023 CAS No.: MDLNo: 分子式: 分子量:
規(guī)格 庫(kù)存 目錄價(jià) 會(huì)員專(zhuān)享價(jià) 數(shù)量
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基本信息
英文名稱(chēng) Recombinant Human Interleukin 17A (rHulL-l7A)
中文名稱(chēng)重組人白介素 17A(rHuIL-17A)
儲(chǔ)存條件Lyophilized samples are stable for 36 months from date of manufacture at -20℃ to -70℃. Upon reconstitution, this cytokine can be stored under sterile conditions at 2- 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
產(chǎn)品詳情

Recombinant human IL-17A is a disulfide-linked homodimer, monomer containing 136 amino acids. Its theoretical molecular mass is 15.5kD and contains glycosylation sites.


Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4+T cells. In addition to Th17 cells, IL-17A can also be produced by various immune cells, including CD8+T cells γδ T cells, natural killer T (NKT) cells, monocytes, and neutrophils. IL-17A plays a crucial role in the host's defense mechanisms against many bacterial and fungal pathogens, as well as in allergic and autoimmune responses. IL-17A plays a role in viral infection by promoting neutrophil inflammation. IL-17A is a homodimeric cytokine with similar biological activity to IL-17F. IL-17A and IL-17RA have high affinity binding, and IL-17RA is essential for the biological activity of IL-17A. IL-17A cannot bind to T cells, B cells, and myeloid cells lacking IL-17RA. IL-17A is associated with various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. IL-17A also plays a pathogenic role in cancer. During tumor development, IL-17A recruits bone marrow-derived suppressor cells (MDSCs) to suppress anti-tumor immunity. IL-17A also promotes tumor growth in vivo by inducing IL-6.

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