英文名稱 | Anti-Human CD3xCEACAM5 Bispecific Antibody(Cibisatamab) |
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中文名稱 | 賽必妥單抗 |
CAS號 | 2101242-53-7 |
英文名稱 | Anti-Human CD3xCEACAM5 Bispecific Antibody(Cibisatamab) |
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中文名稱 | 賽必妥單抗 |
CAS號 | 2101242-53-7 |
Cibisatamab is a T-cell bispecific antibody designed to target carcinoembryonic antigen (CEA) on tumor cells and CD3 on T cells, activating T cells to selectively eliminate CEA-expressing tumors. This humanized antibody has a 2:1 molecular format, enhancing CEA avidity for effective tumor cell targeting. Cibisatamab (CEA-TCB) can be used for colorectal cancer research.
PMID: 30982469 PMCID: PMC6463631 DOI: 10.1186/s40425-019-0575-3