英文名稱 | Anti-Human Her2xHer3 (Zenocutuzumab; MCLA-128; PB4188; R040517) |
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中文名稱 | 澤妥珠單抗 |
CAS號 | 1969309-56-5 |
儲存條件 | store at -20°C |
英文名稱 | Anti-Human Her2xHer3 (Zenocutuzumab; MCLA-128; PB4188; R040517) |
---|---|
中文名稱 | 澤妥珠單抗 |
CAS號 | 1969309-56-5 |
儲存條件 | store at -20°C |
Zenocutuzumab is a bispecific antibody targeting HER2 and HER3, effectively inhibiting NRG1-driven tumor growth. It employs a 'Dock & Block?' mechanism, preventing NRG1 binding to HER3 and subsequent oncogenic signaling.
PMID: 35135829 PMCID: PMC9394398 DOI: 10.1158/2159-8290.CD-21-1119