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庫存

目錄價(jià)

會(huì)員專享價(jià)

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基本信息

英文名稱	Anti-Human IGF1RxHer3 Bispecific Antibody (Istiratumab; MM 141; MM-005)
中文名稱	艾司妥單抗
CAS號(hào)	1509928-04-4

產(chǎn)品詳情

Istiratumab, a bispecific mAb against IGF-1R and ErbB3, promotes receptor degradation via proteasomes, inhibiting AKT in pancreatic cancer cells and blocking PI3K/MAPK in ovarian cancer. It enhances chemo efficacy, potentiating paclitaxel, cisplatin, and doxorubicin in preclinical studies.

相關(guān)文獻(xiàn)

Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE).

PMID: 31912800 DOI: 10.1016/j.annonc.2019.09.004

PMID: 29549161 DOI: 10.1158/1078-0432.CCR-17-2262

PMID: 31728045 PMCID: PMC6856132 DOI: 10.1038/s41598-019-53322-y

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艾司妥單抗

Anti-Human IGF1RxHer3 Bispecific Antibody (Istiratumab; MM 141; MM-005)

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