Obicetrapib (Synonyms: TA-8995; DEZ-001); CAS :866399-87-3

規(guī)格	庫存	目錄價	會員專享價	數(shù)量
1 mg	3-5 days	￥1288.00	登錄后可見	- +
2 mg	3-5 days	￥1936.00	登錄后可見	- +
5 mg	3-5 days	￥2996.00	登錄后可見	- +
10 mg	3-5 days	￥4788.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

1 mg

3-5 days

￥1288.00

登錄后可見

- +

2 mg

3-5 days

￥1936.00

登錄后可見

- +

5 mg

3-5 days

￥2996.00

登錄后可見

- +

10 mg

3-5 days

￥4788.00

登錄后可見

- +

基本信息

英文名稱	Obicetrapib (Synonyms: TA-8995; DEZ-001)
中文名稱	4-（2-（（3,5-雙（三氟甲基）芐基）（（2R，4S）-1-（乙氧羰基）-2-乙基-6-（三氟甲烷）-1,2,3,4-四氫喹啉-4-基）氨基）嘧啶-5-基）氧基）丁酸
CAS號	866399-87-3
分子式	C32H31F9N4O5
分子量	722.60
MDL	MFCD30533470
外觀	White to light yellow powder
儲存條件	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

產(chǎn)品詳情

Obicetrapib, also known as AMG-899, TA-8995, and DEX-001, is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction. TA-8995 dose dependently increased not only total and non-ABCA1-specific CEC but also ABCA1-specific CEC and preBeta-1 HDL particle levels.

相關(guān)文獻(xiàn)

Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects.

PMID: 24628035 PMCID: PMC4243901 DOI: 10.1111/bcp.12380

PMID: 26047975 DOI: 10.1016/S0140-6736(15)60158-1

PMID: 27171534 DOI: 10.1080/14779072.2016.1189327

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CL3123

4-（2-（（3,5-雙（三氟甲基）芐基）（（2R，4S）-1-（乙氧羰基）-2-乙基-6-（三氟甲烷）-1,2,3,4-四氫喹啉-4-基）氨基）嘧啶-5-基）氧基）丁酸

866399-87-3 98+% 3-5 days