BAN ORL 24 | 1401463-54-4

規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
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規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

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基本信息

英文名稱	BAN ORL 24 2HCl \| BAN-ORL-24 2HCl
中文名稱	BAN ORL 24 2HCl \| BAN-ORL-24 2HCl
CAS號(hào)	1401463-54-4
分子式	C27H35N3O2·2HCl
分子量	506.51 \| 433.60 (free)
外觀	White to off-white powder
儲(chǔ)存條件	-20°C, protect from light, stored under nitrogen

產(chǎn)品詳情

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (K_i = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor). It is selective for NOP receptors over μ-, δ-, and κ-opioid receptors (K_is = 0.19, 0.34, and >1 μM, respectively). BAN ORL 24 reduces NOP-induced GTPγS binding (pA₂ = 9.98) and calcium mobilization (K_B = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of μ-opioid and NOP receptors BPR1M97 in mice.

相關(guān)文獻(xiàn)

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine.

https://doi.org/10.1016/j.neuropharm.2019.107678

PMID: 19445927 DOI: 10.1016/j.ejphar.2009.04.054

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