23604-59-5 | TMC 435350 | 司美匹韋 | Simeprevir | TMC435

規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專(zhuān)享價(jià)	數(shù)量
2 mg	3-5days	￥436.00	登錄后可見(jiàn)	- +
5 mg	3-5days	￥688.00	登錄后可見(jiàn)	- +
10 mg	3-5days	￥1066.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專(zhuān)享價(jià)

數(shù)量

2 mg

3-5days

￥436.00

登錄后可見(jiàn)

- +

5 mg

3-5days

￥688.00

登錄后可見(jiàn)

- +

10 mg

3-5days

￥1066.00

登錄后可見(jiàn)

- +

基本信息

英文名稱(chēng)	Simeprevir \| TMC435 \| HSDB 8227
中文名稱(chēng)	西咪匹韋 \| 司美匹韋 \| 西米普韋
CAS號(hào)	923604-59-5
分子式	C38H47N5O7S2
分子量	749.94
外觀	White to off-white powder
儲(chǔ)存條件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

產(chǎn)品詳情

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.

相關(guān)文獻(xiàn)

Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

PMID: 34075346 PMCID: PMC8056950 DOI: 10.1021/acscentsci.0c01186

PMID: 18678486 DOI: 10.1016/j.bmcl.2008.07.088

PMID: 19171797 PMCID: PMC2663092 DOI: 10.1128/AAC.01058-08

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