Go 6983 (also known as GOE-6983; Go-6983; GOE6983; Go6983) is a novel and potent pan-PKC (protein kinase C) inhibitor with potential anticancer and cardioprotective activity. It inhibits PKCα, PKCβ, PKCγ and PKCδ with IC50s of 7 nM, 7 nM, 6 nM and 10 nM, respectively. Go 6983 shows less potency against PKCζ and is inactive on PKCμ. GO6893 displays cardioprotective properties and can reduce polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. When tested with MCF-7 and T47D cells, Go 6983 showed reversible effect on the down-regulation of PKCαand PKCδ induced by PKC activator PDBu, while decreased the expression of PKCη which up-regulated by PDBu.