Midostaurin | PKC412 | CGP 41231 | CGP 41251| CAS 120685-11-2 |PKC

規(guī)格	庫存	目錄價	會員專享價	數(shù)量
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規(guī)格

庫存

目錄價

會員專享價

數(shù)量

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基本信息

英文名稱	Midostaurin \| PKC412 \| CGP 41231 \| CGP 41251
中文名稱	米哚妥林
CAS號	120685-11-2
分子式	C35H30N4O4
分子量	570.64
外觀	White to yellow powder
儲存條件	-20°C, sealed storage, away from moisture

產(chǎn)品詳情

PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.

相關(guān)文獻

Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent

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PKC412--a protein kinase inhibitor with a broad therapeutic potential.

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Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse.

PMID: 15890550 DOI: 10.1016/j.niox.2005.04.001

ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412.

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