英文名稱 | SRT 1720 |
---|---|
中文名稱 | SRT 1720 |
CAS號 | 925434-55-5 |
分子式 | C25H23N7OS |
分子量 | 469.56 |
英文名稱 | SRT 1720 |
---|---|
中文名稱 | SRT 1720 |
CAS號 | 925434-55-5 |
分子式 | C25H23N7OS |
分子量 | 469.56 |
SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.
Are sirtuins viable targets for improving healthspan and lifespan?
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
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SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
PMID: 22546858 PMCID: PMC3366403 DOI: 10.1172/JCI60132