Ifenprodil is a phenylethanolamine, which stimulates blood circulation. It has anticonvulsant and antinociceptive properties. Ifenprodil is used to treat posttraumatic stress disorder, cerebrovascular diseases and peripheral arterial obliterative disease. It blocks G protein-coupled inwardly-rectifying potassium channels (GIRKs) and interacts with α1 adrenergic, N-methyl-D-aspartate and serotonin receptors.
Ifenprodil (+)-tartrate salt has been used:
to test the action in a KCl-induced cortical spreading depression (CSD) animal
to study its effects on electrophysiological properties and spontaneous spikes in neocortical pyramidal cells
to investigate its therapeutic effects.