Motesanib (Synonyms: AMG 706；莫替沙尼 ) CAS: 453562-69-1

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庫存

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基本信息

英文名稱	Motesanib (Synonyms: AMG 706；莫替沙尼 )
中文名稱	N-(3,3-二甲基吲哚啉-6-基)-2-((吡啶-4-基甲基)氨基)煙酰胺
CAS號	453562-69-1
分子式	C22H23N5O
分子量	373.45
MDL	MFCD10567689
外觀	White to khaki powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.

相關文獻

Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors.

PMID: 19118038 DOI: 10.1158/1078-0432.CCR-08-1155

AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts.

PMID: 16951187 DOI: 10.1158/0008-5472.CAN-05-4665

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PMID: 20507929 PMCID: PMC3216115 DOI: 10.1158/1078-0432.CCR-09-3385

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