英文名稱 | Tacrolimus | Fujimycin | FR900506 | FK506 |
---|---|
中文名稱 | 他克莫司 |
CAS號 | 104987-11-3 |
分子式 | C44H69NO12 |
分子量 | 804.02 |
外觀 | White to off-white powder |
儲存條件 | 4°C, protect from light |
英文名稱 | Tacrolimus | Fujimycin | FR900506 | FK506 |
---|---|
中文名稱 | 他克莫司 |
CAS號 | 104987-11-3 |
分子式 | C44H69NO12 |
分子量 | 804.02 |
外觀 | White to off-white powder |
儲存條件 | 4°C, protect from light |
Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
PMID: 27518770 PMCID: PMC5114712 DOI: 10.1007/s10545-016-9959-4
Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo.
PMID: 24912495 PMCID: PMC4094770 DOI: 10.3892/mmr.2014.2302
PMID: 22130237 DOI: 10.1248/bpb.34.1823