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鹽酸吉西他濱

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Gemcitabine Hydrochloride | Gemcitabine HCl | LY 188011 hydrochloride | NSC 613327 HCl

產(chǎn)品編號：CL1996A CAS No.：122111-03-9 MDLNo： 分子式：C?H??ClF?N?O? 分子量：299.66

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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
250 mg	In-stock	￥100.00	登錄后可見	- +
500 mg	In-stock	￥150.00	登錄后可見	- +
1 g	In-stock	￥250.00	登錄后可見	- +
5 g	In-stock	￥400.00	登錄后可見	- +

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基本信息

英文名稱	Gemcitabine Hydrochloride \| Gemcitabine HCl \| LY 188011 hydrochloride \| NSC 613327 HCl
中文名稱	鹽酸吉西他濱
CAS號	122111-03-9
分子式	C?H??ClF?N?O?
分子量	299.66
外觀	White to off-white powder
儲存條件	4°C, sealed storage, away from moisture and light

產(chǎn)品詳情

Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 and gemcitabine elaidate and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate and the active di- and triphosphate forms.It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models. Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma. Formulations containing gemcitabine have been used in the treatment of cancer.

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CL1996A

鹽酸吉西他濱

122111-03-9 98+% In-stock

￥100.00 250 mg