英文名稱 | Amphotericin B | NSC 527017 | LNS-AmB |
---|---|
中文名稱 | 兩性霉素 B |
CAS號 | 1397-89-3 |
分子式 | C47H73NO17 |
分子量 | 924.09 |
外觀 | Yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Amphotericin B | NSC 527017 | LNS-AmB |
---|---|
中文名稱 | 兩性霉素 B |
CAS號 | 1397-89-3 |
分子式 | C47H73NO17 |
分子量 | 924.09 |
外觀 | Yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
Amphotericin B binds ergosterol and induces membrane pore formations, increasing ROS and suppressing fungal growth. It also increases expression of IL-1-beta, TNF-alpha, BDNF and GDNF and protects against prion-induced neurodegeneration.