英文名稱 | Trabectedin | Ecteinascidin 743 | ET-743 |
---|---|
中文名稱 | 他比特啶 | 曲貝替定 |
CAS號 | 114899-77-3 |
分子式 | C39H43N3O11S |
分子量 | 761.84 |
外觀 | White to light yellow powder |
儲存條件 | -20°C, protect from light, stored under nitrogen |
英文名稱 | Trabectedin | Ecteinascidin 743 | ET-743 |
---|---|
中文名稱 | 他比特啶 | 曲貝替定 |
CAS號 | 114899-77-3 |
分子式 | C39H43N3O11S |
分子量 | 761.84 |
外觀 | White to light yellow powder |
儲存條件 | -20°C, protect from light, stored under nitrogen |
Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research.
PMID: 23792433 DOI: 10.1016/j.toxlet.2013.06.213
PMID: 12460906
Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.
PMID: 20215499 DOI: 10.1158/0008-5472.CAN-09-2335