英文名稱 | Polmacoxib |
---|---|
中文名稱 | 帕馬考昔 | 泊馬昔布 |
CAS號(hào) | 301692-76-2 |
分子式 | C18H16FNO4S |
分子量 | 361.39 |
外觀 | Light yellow to green yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Polmacoxib |
---|---|
中文名稱 | 帕馬考昔 | 泊馬昔布 |
CAS號(hào) | 301692-76-2 |
分子式 | C18H16FNO4S |
分子量 | 361.39 |
外觀 | Light yellow to green yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Polmacoxib (CG 100649) is a first-in-class NSAID drug candidate, is a dual inhibitor of carbonic anhydrase (CA) and COX-2. Polmacoxib inhibits premalignant and malignant colorectal lesions in mouse models, partly through inhibiting tumor cell proliferation.
CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models.
PMID: 28421763 DOI: 10.1021/acs.jmedchem.7b00010
ynthetic Approaches to the New Drugs Approved During 2015
PMID: 28421763 DOI: 10.1021/acs.jmedchem.7b00010