英文名稱 | AZ-5104 |
---|---|
中文名稱 | AZ-5104 |
CAS號 | 1421373-98-9 |
分子式 | C27H31N7O2 |
分子量 | 485.58 |
外觀 | White to yellow powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
英文名稱 | AZ-5104 |
---|---|
中文名稱 | AZ-5104 |
CAS號 | 1421373-98-9 |
分子式 | C27H31N7O2 |
分子量 | 485.58 |
外觀 | White to yellow powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
AZ5104 (AZ-5104), a demethylated and active metabolite of Osimertinib (AZD-9291), is an irreversible EGFR inhibitor with potential antitumor activity. Its IC50 values are 1, 6, 1, 25, and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR, and ErbB4 inhibition, respectively. A novel and selective third-generation irreversible inhibitor, AZD9291 spares wild-type EGFR while inhibiting both EGFRm(+) sensitizing and T790M resistance mutants.