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首頁 > 產(chǎn)品目錄 > 信號通路 > Membrane Transporter/Ion Channel > SGLT > (2S,3R,4R,5S,6R)-2-(4-氯-3-(4-乙氧基芐基)苯基)-6-(羥甲基)四氫-2H-吡喃-3,4,5-三醇

(2S,3R,4R,5S,6R)-2-(4-氯-3-(4-乙氧基芐基)苯基)-6-(羥甲基)四氫-2H-吡喃-3,4,5-三醇

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Dapagliflozin (BMS-512148; 達(dá)格列凈)

產(chǎn)品編號:CL1127 CAS No.:461432-26-8 MDLNo:MFCD13182359 分子式:C21H25ClO6 分子量:408.87
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
100 mg In-stock ¥566.00 登錄后可見
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250 mg In-stock ¥788.00 登錄后可見
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500 mg In-stock ¥1488.00 登錄后可見
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基本信息
英文名稱 Dapagliflozin (BMS-512148; 達(dá)格列凈)
中文名稱(2S,3R,4R,5S,6R)-2-(4-氯-3-(4-乙氧基芐基)苯基)-6-(羥甲基)四氫-2H-吡喃-3,4,5-三醇
CAS號461432-26-8
分子式C21H25ClO6
分子量408.87
MDLMFCD13182359
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Dapagliflozin (formerly known as BMS-512148; trade names Farxiga in the US and Forxiga in the EU) is a potent and selective hSGLT2 (sodium-glucose transport proteins) inhibitor with anti-diabetic activity. It inhibits hSGLT2 with an EC50 of 1.1 nM, and exhibits1200-fold selectivity over hSGLT1.  Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Urine is the means by which blood glucose is expelled when this transporter mechanism is blocked.

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