英文名稱 | Temoporfin | KW-2345 | m-THPC |
---|---|
中文名稱 | 替莫泊芬 | 替莫卟吩 | 2,3-二氫-5,10,15,20-四(間羥苯基)卟啉 |
CAS號 | 122341-38-2 |
分子式 | C44H32N4O4 |
分子量 | 680.75 |
外觀 | Black purple powder |
儲存條件 | -20°C, protect from light, stored under nitrogen |
英文名稱 | Temoporfin | KW-2345 | m-THPC |
---|---|
中文名稱 | 替莫泊芬 | 替莫卟吩 | 2,3-二氫-5,10,15,20-四(間羥苯基)卟啉 |
CAS號 | 122341-38-2 |
分子式 | C44H32N4O4 |
分子量 | 680.75 |
外觀 | Black purple powder |
儲存條件 | -20°C, protect from light, stored under nitrogen |
Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells , When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor. Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.
Temoporfin (Foscan®, 5,10,15,20-tetra(m-hydroxyphenyl)chlorin)--a second-generation photosensitizer.
PMID: 21848905 DOI: 10.1111/j.1751-1097.2011.00986.x
PMID: 24143087 PMCID: PMC3797282 DOI: 10.2147/IJN.S51002
PMID: 10574244 PMCID: PMC2362893 DOI: 10.1038/sj.bjc.6690736