Streptozotocin | Streptozocin | Streptozocin | NSC-85998 | U 9889 | CAS: 18883-66-4

規(guī)格	庫存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
50 mg	In-stock	￥316.00	登錄后可見	- +
100 mg	In-stock	￥466.00	登錄后可見	- +
200 mg	In-stock	￥788.00	登錄后可見	- +

規(guī)格

庫存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

50 mg

In-stock

￥316.00

登錄后可見

- +

100 mg

In-stock

￥466.00

登錄后可見

- +

200 mg

In-stock

￥788.00

登錄后可見

- +

基本信息

英文名稱	Streptozotocin (Synonyms: Streptozocin; Streptozocin; NSC-85998; U 9889)
中文名稱	1-甲基-1-亞硝基-3-((2S,3R,4R,5S,6R)-2,4,5-三羥基-6-(羥甲基)四氫-2H-吡喃-3-基)脲; 鏈脲菌素; 鏈脲佐菌素
CAS號(hào)	18883-66-4
分子式	C8H15N3O7
分子量	265.22
MDL	MFCD00006607
外觀	Light yellow powder
儲(chǔ)存條件	-20°C, sealed storage, away from moisture and light

產(chǎn)品詳情

Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.

相關(guān)文獻(xiàn)

Outbred Mice with Streptozotocin-Induced Diabetes Show Sex Differences in Glucose Metabolism.

Int J Mol Sci. 2023 Mar 8;24(6):5210.

PMID: 26331889 DOI: 10.1002/0471141755.ph0547s70

PMID: 25573197 DOI: 10.1016/j.imlet.2014.12.006

PMID: 16354401 DOI: 10.1211/jpp.57.12.0007

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CL1016

1-甲基-1-亞硝基-3-((2S,3R,4R,5S,6R)-2,4,5-三羥基-6-(羥甲基)四氫-2H-吡喃-3-基)脲; 鏈脲菌素; 鏈脲佐菌素